Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.62 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713801 | 0.87 | PRKCZ (0.58) | PRKCZCYP17A1CYP19A1TBXAS1CYP11B1 | |
| SCHEMBL26556456 | 0.86 | RAB9A (0.53) | PRKCZCYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL26553186 | 0.86 | RAB9A (0.53) | PRKCZCYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6114863 | 0.85 | CYP1A2 (0.55) | PRKCZCYP19A1TBXAS1ALDH1A1MAPT | |
| SCHEMBL28044803 | 0.83 | PRKCZ (0.67) | PRKCZCYP17A1CYP19A1TBXAS1CYP11B1 | |
| SCHEMBL26556365 | 0.82 | CYP11B2 (0.63) | CYP17A1CYP19A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL26553137 | 0.82 | CYP11B2 (0.63) | CYP17A1CYP19A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL29650645 | 0.81 | PRKCZ (0.75) | PRKCZCYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3322974 | 0.81 | PRKCZ (0.75) | PRKCZCYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL22826623 | 0.81 | PRKCZ (0.44) | PRKCZCYP19A1TBXAS1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018060949-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR USE IN THE TREATMENT OF LIVER DISEASES | ROIVANT SCIENCES GMBH (CH) | 2018-04-05 | — | — | WO | disclosed |