Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CPN1 | P15169 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19035317 | 0.88 | CPN1 (0.40) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL20921369 | 0.85 | TSHR (0.42) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL8738393 | 0.84 | CPN1 (0.37) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL30656282 | 0.84 | LMNA (0.42) | LMNAADRA2AADRA2BADRA2C | |
| SCHEMBL18922904 | 0.83 | CYP3A4 (0.42) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL9402905 | 0.83 | CPN1 (0.49) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL9210125 | 0.82 | CPN1 (0.50) | CYP3A4CPN1CPB2LMNACYP2D6 | |
| SCHEMBL19072669 | 0.82 | HTR2A (0.44) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL15157405 | 0.81 | CYP3A4 (0.44) | CYP3A4CASP1RECQLCPN1CPB2 | |
| SCHEMBL5466349 | 0.81 | LMNA (0.59) | CYP3A4CASP1RECQLCPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11759462-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ALTAVANT SCIENCES GMBH | 2023-09-19 | — | — | US | disclosed |
| WO-2023107687-A1 | INHIBITORS OF MENIN-MLL INTERACTION | BALA THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| EP-3486283-B1 | COMPOSITION AND MOLDED ARTICLE | UNIV AKITA (JP) | 2022-06-15 | — | — | EP | disclosed |
| US-20210205305-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2021-07-08 | — | — | US | disclosed |
| US-10946018-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES GMBH (CH) | 2021-03-16 | — | — | US | disclosed |
| US-10815369-B2 | Composition and molded article | AKITA UNIVERSITY (JP) | 2020-10-27 | — | — | US | disclosed |
| US-20200237760-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ROIVANT SCIENCES GMBH (CH) | 2020-07-30 | — | — | US | disclosed |
| WO-2020132561-A1 | TARGETED PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| US-10660893-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES, GmbH (CH) | 2020-05-26 | — | — | US | disclosed |
| US-20190282575-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2019-09-19 | — | — | US | disclosed |
| CN-1243810-C | Ultraviolet activatable adhesive film | 3M INNOVATIVE PROPERTIES CO (US) | 2006-03-01 | — | — | CN | disclosed |
| CN-1668703-A | Charge transport compositions based on triarylmethanes and their use in electronic devices | DU PONT (US) | 2005-09-14 | — | — | CN | disclosed |
| CN-1555405-A | Cationically polymerizable adhesive composition and anisotropically conductive adhesive composition | 3M | 2004-12-15 | — | — | CN | disclosed |
| CN-1527869-A | Ultraviolet activatable adhesive film | 3M | 2004-09-08 | — | — | CN | disclosed |
| CN-1516727-A | Method for adhering substrates using ultraviolet activatable adhesive film and ultraviolet irradiation apparatus | 3M | 2004-07-28 | — | — | CN | disclosed |
| CN-1505672-A | Method for adhering substrates using light activatable adhesive film | 3M | 2004-06-16 | — | — | CN | disclosed |
| CN-1036781-C | N-aryl and n-cycloakyl neoalkanamide insect repellents | COLGATE PALMOLIVE CO (US) | 1997-12-24 | — | — | CN | disclosed |
| CN-1030074-C | N-aryl and N-cycloalkyl neoalkanamide insect repellents | COLGATO PALMOLIVO CO (US) | 1995-10-18 | — | — | CN | disclosed |
| CN-1109869-A | N-aryl and n-cycloakyl neoalkanamide insect repellents | COLGATE PALMOLIVE CO (US) | 1995-10-11 | — | — | CN | disclosed |
| CN-1064266-A | N-aryl and N-cycloalkyl neoalkanamide insect repellents | COLGATE PALMOLIVE CO (US) | 1992-09-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10660893-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | CYP3A4 234/4885CASP1 1372/4885RECQL 2911/4885 |
| US-20200237760-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | CYP3A4 234/4885CASP1 1372/4885RECQL 2911/4885 |
| US-20210205305-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | CYP3A4 234/4885CASP1 1372/4885RECQL 2911/4885 |
| US-11759462-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | CYP3A4 234/4885CASP1 1372/4885RECQL 2911/4885 |
| US-20190282575-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | CYP3A4 234/4885CASP1 1372/4885RECQL 2911/4885 |
| US-10946018-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | CYP3A4 234/4885CASP1 1372/4885RECQL 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.