Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007930 | 0.94 | PLA2G2A (0.38) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL2002951 | 0.92 | S1PR1 (0.41) | NPC1RAB9ALMNASMN1; SMN2TP53 | |
| SCHEMBL2001517 | 0.91 | ALOX5AP (0.42) | NPC1RAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL2003332 | 0.91 | SMN1; SMN2 (0.39) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL2002732 | 0.91 | LMNA (0.33) | LMNASMN1; SMN2MAPTF2RL3F10 | |
| SCHEMBL2001583 | 0.90 | LMNA (0.40) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL2007825 | 0.89 | TP53 (0.43) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL2002547 | 0.88 | RAB9A (0.39) | NPC1RAB9ALMNASMN1; SMN2HPGD | |
| SCHEMBL2003150 | 0.88 | S1PR1 (0.35) | LMNASMN1; SMN2HPGDS1PR1MAPT | |
| SCHEMBL2008151 | 0.88 | LMNA (0.39) | NPC1RAB9ALMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |