Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003255 | 0.94 | NPC1 (0.38) | TP53SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL2003332 | 0.93 | SMN1; SMN2 (0.39) | TP53SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL2002120 | 0.91 | ABCB1 (0.41) | PLA2G2APTGS2TP53SMN1; SMN2NPC1 | |
| SCHEMBL2007825 | 0.91 | TP53 (0.43) | TP53SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL2005271 | 0.91 | TSHR (0.43) | PLA2G2APTGS2TP53SMN1; SMN2LMNA | |
| SCHEMBL2002547 | 0.90 | RAB9A (0.39) | TP53SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL2007846 | 0.90 | NPC1 (0.40) | PLA2G2ATP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2003162 | 0.90 | PLA2G2A (0.37) | PLA2G2APTGS2TP53LMNATSHR | |
| SCHEMBL2005858 | 0.89 | PLA2G2A (0.44) | PLA2G2ATP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2002603 | 0.88 | MAPT (0.40) | TP53SMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |