Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16614191 | 0.89 | TDP1 (0.68) | TDP1RAB9APOLBAPEX1RECQL | |
| SCHEMBL18084701 | 0.87 | TDP1 (0.60) | TDP1RAB9APOLBAPEX1RECQL | |
| SCHEMBL1092598 | 0.81 | TDP1 (0.77) | TDP1RAB9APOLBAPEX1RECQL | |
| SCHEMBL8690783 | 0.78 | TDP1 (1.00) | TDP1RAB9APOLBAPEX1RECQL | |
| SCHEMBL8691132 | 0.77 | TDP1 (0.74) | TDP1RAB9APOLBAPEX1RECQL | |
| SCHEMBL20032577 | 0.76 | KMO (0.39) | TDP1KMOAKR1B1MAOA | |
| SCHEMBL20032580 | 0.75 | KMO (0.37) | TDP1POLBAPEX1RECQLKMO | |
| SCHEMBL20032574 | 0.75 | CTNNB1 (0.51) | RAB9AKMONPC1KDM4E | |
| SCHEMBL16742309 | 0.74 | TDP1 (0.70) | TDP1RAB9APOLBAPEX1RECQL | |
| SCHEMBL10776603 | 0.74 | TDP1 (0.70) | TDP1RAB9APOLBAPEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938252-B2 | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-04-10 | — | — | US | disclosed |