Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18066728 | 0.90 | KMO (0.49) | KMOSSTR5MAPTRXRAHTR2A | |
| SCHEMBL103150 | 0.80 | MAPT (0.47) | SSTR5MAPTRXRAPOLBAPEX1 | |
| SCHEMBL10407993 | 0.78 | MAPT (0.44) | SSTR5MAPTRXRAHTR2APOLB | |
| SCHEMBL2812534 | 0.77 | RXRA (0.52) | SSTR5MAPTRXRAPOLBALDH1A1 | |
| SCHEMBL20032573 | 0.75 | TDP1 (0.63) | KMOMAPTPOLBAPEX1RECQL | |
| SCHEMBL20032574 | 0.74 | CTNNB1 (0.51) | KMOKDM4E | |
| SCHEMBL15947259 | 0.73 | MAPT (0.47) | SSTR5MAPTALDH1A1KDM4ETDP1 | |
| SCHEMBL9873185 | 0.70 | MAPT (0.38) | SSTR5MAPTRXRAHTR2APOLB | |
| SCHEMBL2811130 | 0.70 | CA12 (0.48) | MAPTRECQLALDH1A1KDM4EHPGD | |
| Acetic Acid SCHEMBL28623911 | 0.69 | MAPT (0.41) | SSTR5MAPTHTR2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938252-B2 | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-04-10 | — | — | US | disclosed |