Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.51 |
| ▸ | WNT3A | P56704 | 7/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PIR | O00625 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16614190 | 0.88 | CTNNB1 (0.55) | CTNNB1WNT3APRKCICACNA1HTAS1R3 | |
| SCHEMBL1726294 | 0.80 | CTNNB1 (0.61) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL15337102 | 0.80 | KMO (0.52) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL7057339 | 0.76 | CTNNB1 (0.56) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL20032579 | 0.75 | CTNNB1 (0.52) | CTNNB1WNT3ARAB9AKDM4EKMO | |
| SCHEMBL875455 | 0.75 | CTNNB1 (0.67) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL31262479 | 0.75 | CTNNB1 (0.67) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL16599887 | 0.75 | KMO (0.48) | CTNNB1WNT3APRKCICACNA1HACHE | |
| SCHEMBL16599885 | 0.75 | KMO (0.48) | CTNNB1WNT3APRKCICACNA1HACHE | |
| SCHEMBL20032573 | 0.75 | TDP1 (0.63) | NPC1RAB9AKDM4EKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938252-B2 | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-04-10 | — | — | US | disclosed |