Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20032578 | 0.89 | KMO (0.40) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL18066729 | 0.88 | KMO (0.55) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL21231344 | 0.88 | KMO (0.55) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL18084718 | 0.87 | NPC1 (0.46) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL20032576 | 0.80 | KMO (0.40) | NPC1RAB9AKMO | |
| SCHEMBL21231436 | 0.77 | KMO (0.55) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL16600215 | 0.77 | KMO (0.55) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL18084705 | 0.76 | PLK1 (0.43) | NPC1RAB9AKMOMEN1KMT2A | |
| SCHEMBL3705853 | 0.75 | ALDH1A1 (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL20032572 | 0.74 | KMO (0.37) | KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938252-B2 | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-04-10 | — | — | US | disclosed |