Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16614189 | 0.90 | KMO (0.52) | KMOAKR1B1NPC1RAB9AHSD11B1 | |
| SCHEMBL21231341 | 0.90 | KMO (0.52) | KMOAKR1B1NPC1RAB9AHSD11B1 | |
| SCHEMBL21231715 | 0.90 | KMO (0.52) | KMOAKR1B1NPC1RAB9AHSD11B1 | |
| SCHEMBL18084708 | 0.87 | KMO (0.38) | KMONPC1RAB9A | |
| SCHEMBL20032575 | 0.80 | NPC1 (0.45) | KMONPC1RAB9A | |
| SCHEMBL20032578 | 0.80 | KMO (0.40) | KMONPC1RAB9A | |
| SCHEMBL20032577 | 0.78 | KMO (0.39) | KMOAKR1B1 | |
| SCHEMBL20032572 | 0.73 | KMO (0.37) | KMO | |
| SCHEMBL21231436 | 0.68 | KMO (0.55) | KMONPC1RAB9A | |
| SCHEMBL21231344 | 0.68 | KMO (0.55) | KMONPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938252-B2 | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-04-10 | — | — | US | disclosed |