Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.40 |
| ▸ | MGLL | Q99685 | 4/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19704576 | 0.93 | OPRM1 (0.39) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL20034917 | 0.92 | PTGS1 (0.40) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL20034933 | 0.86 | MGLL (0.42) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL19703772 | 0.86 | MGLL (0.42) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL19703768 | 0.85 | MGLL (0.44) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL19703767 | 0.85 | MGLL (0.44) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL19698171 | 0.83 | DRD2 (0.39) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL19703781 | 0.82 | LMNA (0.42) | MGLLFAAHOPRM1OPRD1OPRK1 | |
| SCHEMBL19698161 | 0.82 | MGLL (0.41) | PTGS1PTGS2MGLLFAAHOPRM1 | |
| SCHEMBL19698172 | 0.82 | MGLL (0.41) | PTGS1PTGS2MGLLFAAHOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |