Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005916 | 0.94 | SMPD1 (0.35) | MAPTPKMALDH1A1SMPD1LMNA | |
| SCHEMBL2004069 | 0.91 | FAAH (0.43) | MAPTPKMALDH1A1SMPD1LMNA | |
| SCHEMBL2004749 | 0.90 | L3MBTL1 (0.36) | MAPTGAAPKMALDH1A1LMNA | |
| SCHEMBL2002296 | 0.90 | MAPT (0.33) | MAPTGAAPKMALDH1A1SMPD1 | |
| SCHEMBL2000418 | 0.89 | MEN1 (0.43) | MAPTPKMALDH1A1SMPD1LMNA | |
| SCHEMBL2003750 | 0.89 | FAAH (0.40) | MAPTGAAPKMALDH1A1SMPD1 | |
| SCHEMBL2003774 | 0.89 | CNR1 (0.38) | MAPTALDH1A1LMNAKDM4EMAPK1 | |
| SCHEMBL2007692 | 0.88 | ALOX5AP (0.39) | MAPTPKMALDH1A1SMPD1LMNA | |
| SCHEMBL2003476 | 0.88 | SMPD1 (0.41) | MAPTGAAPKMALDH1A1SMPD1 | |
| SCHEMBL2007820 | 0.85 | LMNA (0.37) | MAPTGAAPKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |