Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003287 | 0.95 | LMNA (0.34) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2007239 | 0.91 | TP53 (0.35) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2002897 | 0.90 | LMNA (0.40) | LMNAALDH1A1MAPTALOX12SMN1; SMN2 | |
| SCHEMBL2003479 | 0.90 | MAPT (0.36) | L3MBTL1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2007750 | 0.90 | L3MBTL1 (0.34) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2003124 | 0.90 | PLA2G2A (0.37) | L3MBTL1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2006491 | 0.90 | GRM5 (0.42) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2003234 | 0.89 | LMNA (0.35) | LMNAMAPTSMN1; SMN2TP53CYP2C9 | |
| SCHEMBL2000325 | 0.89 | RAB9A (0.41) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2006939 | 0.86 | L3MBTL1 (0.37) | L3MBTL1LMNAALDH1A1MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |