Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254104 | 0.98 | FAAH (0.44) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL18159035 | 0.85 | FAAH (0.38) | FAAHKMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL14996240 | 0.84 | TSHR (0.43) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL20034909 | 0.83 | FAAH (0.37) | FAAHKMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL16213686 | 0.82 | FAAH (0.41) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL22886704 | 0.82 | FAAH (0.41) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL21016081 | 0.82 | FAAH (0.45) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL22872813 | 0.81 | FAAH (0.44) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL21016151 | 0.81 | FAAH (0.40) | FAAHKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL26691656 | 0.81 | FAAH (0.44) | FAAHKMT2AMEN1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |