Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | CASP2 | P42575 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20034810 | 0.83 | FAAH (0.41) | FAAHKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL254104 | 0.82 | FAAH (0.44) | FAAHKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18159035 | 0.79 | FAAH (0.38) | FAAHKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19224050 | 0.75 | MEN1 (0.57) | KMT2AMEN1ALDH1A1SMN1; SMN2CASP2 | |
| SCHEMBL19703570 | 0.75 | ALDH1A1 (0.39) | FAAHKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19703878 | 0.74 | FAAH (0.62) | FAAHKMT2AMEN1DPP7CASP2 | |
| SCHEMBL1059272 | 0.74 | OTC (0.54) | TSHR | |
| SCHEMBL515567 | 0.74 | OTC (0.54) | TSHR | |
| SCHEMBL14282705 | 0.74 | FOLH1 (0.40) | FAAHKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL23584015 | 0.73 | FAAH (0.66) | FAAHKMT2AMEN1CASP2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |