Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037171 | 0.89 | KLK7 (0.50) | LMNAALDH1A1HTTKLK7SMN1; SMN2 | |
| SCHEMBL20037101 | 0.87 | KLK7 (0.55) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 | |
| SCHEMBL20037030 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 | |
| SCHEMBL20037237 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 | |
| SCHEMBL20037029 | 0.85 | ALDH1A1 (0.49) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 | |
| SCHEMBL20037121 | 0.85 | ALDH1A1 (0.52) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 | |
| SCHEMBL20037202 | 0.85 | KLK7 (0.54) | ALDH1A1HTTKLK7L3MBTL1NPC1 | |
| SCHEMBL20037052 | 0.82 | ALDH1A1 (0.54) | LMNAALDH1A1HTTKLK7SMN1; SMN2 | |
| SCHEMBL20037082 | 0.80 | KLK7 (0.53) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 | |
| SCHEMBL20037302 | 0.80 | KLK7 (0.45) | ALDH1A1HTTKLK7SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |