Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12697198 | 0.82 | RRM2 (0.46) | MAPTKCNQ3KCNQ2HDAC1HDAC6 | |
| SCHEMBL25650053 | 0.81 | STK17A (0.42) | MAPTKCNQ3KCNQ2HDAC1HDAC6 | |
| SCHEMBL9347587 | 0.81 | NPSR1 (0.40) | MAPTKCNQ3KCNQ2HDAC1HDAC6 | |
| SCHEMBL14197601 | 0.79 | RRM2 (0.48) | MAPTKCNQ3KCNQ2HDAC1HDAC6 | |
| SCHEMBL20929322 | 0.79 | MAPT (0.42) | MAPTHDAC1HDAC6GAAKDM4E | |
| SCHEMBL12788678 | 0.78 | SLC22A12 (0.41) | MAPTKCNQ3KCNQ2HDAC1HDAC6 | |
| SCHEMBL3632606 | 0.78 | ADRA2A (0.50) | MAPTKCNQ3KCNQ2HDAC1HDAC6 | |
| SCHEMBL24124016 | 0.77 | MAPT (0.39) | MAPTGAASLC22A12KDM4EALDH1A1 | |
| SCHEMBL20037649 | 0.77 | MAPT (0.35) | MAPTGAASTK17ATAAR1 | |
| SCHEMBL18386498 | 0.77 | KCNH3 (0.48) | NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |