Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028649 | 0.84 | GCK (0.43) | GCKKDRSCN9ATGFBR1NR4A1 | |
| SCHEMBL4328013 | 0.81 | NOS3 (0.55) | SCN9ANR4A1KCNH2SCN5AMAPT | |
| SCHEMBL4794755 | 0.81 | NR4A1 (0.44) | SCN9ANR4A1MAPTMEN1HPGD | |
| SCHEMBL4363033 | 0.81 | ALDH1A1 (0.46) | GCKKDRSCN9ATGFBR1NR4A1 | |
| SCHEMBL16904536 | 0.78 | KDR (0.58) | KDR | |
| SCHEMBL29788826 | 0.78 | KDR (0.58) | KDR | |
| SCHEMBL486670 | 0.78 | NR4A1 (0.61) | NR4A1MAPTMEN1HPGDKMT2A | |
| SCHEMBL4795766 | 0.77 | NR4A1 (0.47) | KDRSCN9ANR4A1RAF1MAPT | |
| SCHEMBL13504249 | 0.77 | RIOK2 (0.48) | GCKKDRMAPTSMN1; SMN2NPC1 | |
| SCHEMBL4363640 | 0.76 | GCK (0.51) | GCKKDRTGFBR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |