Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | BAX | Q07812 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44951 | 0.81 | — | — | |
| SCHEMBL19676366 | 0.80 | LMNA (0.53) | HPGDSMN1; SMN2LTA4HHTTALDH1A1 | |
| SCHEMBL28101904 | 0.79 | HPGD (0.57) | HPGDSMN1; SMN2ALDH1A1MAPTPGR | |
| Hydrochloric Acid SCHEMBL6761971 | 0.79 | KCNH3 (0.47) | SMN1; SMN2HTTALDH1A1MAPTTSHR | |
| Fluoride SCHEMBL28139765 | 0.79 | PHGDH (0.46) | SMN1; SMN2HTTALDH1A1MAPTTSHR | |
| Hydrochloric Acid SCHEMBL892263 | 0.79 | KCNH3 (0.47) | SMN1; SMN2HTTALDH1A1MAPTTSHR | |
| SCHEMBL28771750 | 0.79 | PHGDH (0.46) | SMN1; SMN2HTTALDH1A1MAPTTSHR | |
| SCHEMBL29910198 | 0.78 | NPC1 (0.41) | HPGDSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5554561 | 0.78 | LTA4H (0.57) | HPGDSMN1; SMN2LTA4HHTTALDH1A1 | |
| SCHEMBL28610810 | 0.77 | PTPN1 (0.47) | HPGDSMN1; SMN2HTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080099-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2018-04-11 | — | — | EP | disclosed |