Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13232649 | 0.83 | LMNA (0.56) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL16114401 | 0.82 | LMNA (0.75) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL11107948 | 0.80 | LMNA (0.62) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL20041022 | 0.80 | HPGD (0.61) | ALDH1A1NPC1RAB9AHTTHPGD | |
| SCHEMBL13707699 | 0.79 | LMNA (0.56) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL25000186 | 0.79 | LMNA (0.51) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL22874526 | 0.79 | TDP1 (0.51) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL4374994 | 0.78 | LMNA (0.55) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL27968872 | 0.78 | LMNA (0.69) | LMNATDP1CYP19A1ALDH1A1NPC1 | |
| SCHEMBL676142 | 0.78 | LMNA (0.82) | LMNATDP1CYP19A1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080098-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-12-06 | — | — | EP | disclosed |