Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 5/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | F13A1 | P00488 | 3/20 | 0.47 |
| ▸ | TGM1 | P22735 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPN | P05981 | 2/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316730 | 0.86 | CTSL (0.53) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL3316725 | 0.86 | CTSL (0.53) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL3313305 | 0.86 | HPN (0.56) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL3313307 | 0.86 | HPN (0.56) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL16664895 | 0.83 | TGM2 (0.55) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL18045067 | 0.83 | TGM2 (0.49) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL3489847 | 0.81 | CTSL (0.62) | TGM2CTSLCTSBCTSKDPP4 | |
| SCHEMBL25203367 | 0.79 | HSD11B1 (0.60) | CTSLCTSBCTSKDPP4DPP7 | |
| SCHEMBL18956862 | 0.78 | CTSL (0.58) | CTSLCTSBCTSKDPP4DPP7 | |
| SCHEMBL22829637 | 0.78 | DPP4 (0.61) | TGM2CTSLCTSBCTSKDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057955-B1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |