SCHEMBL20041681

SCHEMBL20041681

Cc1ccc2oc3c(-c4cccc5c4oc4nc6ccccc6n45)cccc3c2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 1/20 0.40
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
PIM1 P11309 1/20 0.37
CSNK2A2 P19784 1/20 0.37
CSNK2B P67870 1/20 0.37
PIM3 Q86V86 1/20 0.37
PIM2 Q9P1W9 1/20 0.37
ALOX5 P09917 2/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
POLB P06746 3/20 0.35
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.35
TP53 P04637 1/20 0.35
HSD17B10 Q99714 1/20 0.35
HPGD P15428 3/20 0.34
CASP3 P42574 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20041679 0.88 FLT3 (0.41) FLT3NPC1RAB9APIM1CSNK2A2
SCHEMBL20041416 0.87 FLT3 (0.41) FLT3NPC1RAB9APIM1CSNK2A2
SCHEMBL17507361 0.87 NPC1 (0.46) FLT3NPC1RAB9AALOX5POLB
SCHEMBL20041625 0.82 NPC1 (0.41) FLT3NPC1RAB9APIM1CSNK2A2
SCHEMBL17507386 0.80 NPC1 (0.41) FLT3NPC1RAB9AALOX5KDM4E
SCHEMBL22037061 0.79 RAB9A (0.41) FLT3NPC1RAB9APOLBKDM4E
SCHEMBL20041421 0.79 TP53 (0.45) FLT3NPC1RAB9AMAPTLMNA
SCHEMBL12799794 0.78 ALOX5 (0.49) NPC1RAB9APIM1CSNK2A2CSNK2B
SCHEMBL17507339 0.77 FLT3 (0.45) FLT3NPC1RAB9APOLBKDM4E
SCHEMBL20041533 0.77 TP53 (0.43) FLT3NPC1RAB9AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2982676-B1 Benzimidazo[2,1-B]benzoxazoles for electronic applications IDEMITSU KOSAN CO (JP) 2018-04-11 EP disclosed