Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19185731 | 1.00 | KCNH2 (0.41) | KCNH2MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19185634 | 1.00 | KCNH2 (0.41) | KCNH2MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL12527781 | 0.98 | L3MBTL1 (0.38) | KCNH2MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19185580 | 0.91 | NOS2 (0.38) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11976549 | 0.83 | RAB9A (0.39) | KCNH2MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL28055917 | 0.83 | RARB (0.50) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12457576 | 0.81 | DHFR (0.35) | MAPTKDM4EALDH1A1USP2GAA | |
| SCHEMBL13402169 | 0.81 | MEN1 (0.55) | MAPTRAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL17967585 | 0.81 | RAB9A (0.57) | KCNH2MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15894460 | 0.81 | RAB9A (0.41) | KCNH2MAPTRAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509955-B1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS S A (CH) | 2018-04-25 | — | — | EP | disclosed |
| EP-2509974-B1 | PYRAZOLES DERIVATIVES MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL AND METHODS FOR TREATMENT OF NON-SMALL CELL LUNG CANCER | RHIZEN PHARMACEUTICALS S A (CH) | 2018-04-11 | — | — | EP | disclosed |