Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.41 |
| ▸ | HTR7 | P34969 | 7/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994787 | 0.90 | MAPT (0.33) | HTR1AHTR7HTR2BHTR6FLT3 | |
| SCHEMBL1998216 | 0.88 | LMNA (0.42) | FLT3HRH3LMNAALDH1A1GAA | |
| SCHEMBL1998839 | 0.85 | GSK3B (0.34) | HTR1AHTR7HTR2BHTR6FLT3 | |
| SCHEMBL1998682 | 0.81 | MAPT (0.35) | HTR1AHTR7HTR2BHTR6FLT3 | |
| SCHEMBL1998528 | 0.80 | LMNA (0.42) | HTR7HRH3LMNAALDH1A1GAA | |
| SCHEMBL2761010 | 0.78 | MAPT (0.41) | HTR1AHTR7HTR2BHTR6HTR2A | |
| SCHEMBL2761138 | 0.78 | LMNA (0.40) | HTR1AHTR7HTR2BHTR6P4HB | |
| SCHEMBL1995722 | 0.77 | MAPT (0.35) | HTR1AHTR7HTR2BHTR6FLT3 | |
| SCHEMBL1998346 | 0.76 | GSK3B (0.34) | HTR7FLT3LMNAMAPTL3MBTL1 | |
| SCHEMBL2761238 | 0.76 | LMNA (0.51) | HTR1AHTR2BHTR2AHTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960413-B2 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20060276650-A1 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276650-A1 | Pyrazole compounds | HTR1D, HTR1A, HTR3A | HTR1A 2/4885HTR7 16/4885HTR2B 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.