Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998528 | 0.92 | LMNA (0.42) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL1994787 | 0.91 | MAPT (0.33) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL2761238 | 0.89 | LMNA (0.51) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL2004264 | 0.88 | HTR1A (0.41) | LMNAALDH1A1GAAHRH3MAPT | |
| Hydrochloric Acid SCHEMBL1997591 | 0.88 | LMNA (0.50) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL1999587 | 0.88 | LMNA (0.44) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL2761282 | 0.86 | LMNA (0.42) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL1998682 | 0.83 | MAPT (0.35) | LMNAPOLBNPSR1HRH3MAPT | |
| SCHEMBL2006339 | 0.83 | LMNA (0.44) | LMNAPOLBNPSR1ALDH1A1GAA | |
| SCHEMBL1998839 | 0.82 | GSK3B (0.34) | LMNAALDH1A1GAAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960413-B2 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20060276650-A1 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276650-A1 | Pyrazole compounds | HTR1D, HTR1A, HTR3A | LMNA 3297/4885POLB 4167/4885NPSR1 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.