Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042711 | 0.90 | HSD17B10 (0.50) | HSD17B10KMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL20042980 | 0.89 | LSS (0.50) | HSD17B10KMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL20042810 | 0.89 | HSD17B10 (0.46) | HSD17B10KMT2AALDH1A1MEN1GBA1 | |
| SCHEMBL20042751 | 0.85 | HSD17B10 (0.49) | HSD17B10KMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL20042687 | 0.85 | HSD17B10 (0.51) | HSD17B10KMT2AALDH1A1MEN1GBA1 | |
| SCHEMBL20042811 | 0.84 | HSD17B10 (0.60) | HSD17B10KMT2AALDH1A1MEN1GBA1 | |
| SCHEMBL20042715 | 0.81 | HSD17B10 (0.45) | HSD17B10KMT2AALDH1A1MEN1GBA1 | |
| SCHEMBL20042719 | 0.80 | HSD17B10 (0.46) | HSD17B10KMT2AMEN1GBA1POLB | |
| SCHEMBL20042827 | 0.80 | HSD17B10 (0.46) | HSD17B10KMT2AALDH1A1MEN1GBA1 | |
| SCHEMBL20042812 | 0.80 | HSD17B10 (0.46) | HSD17B10KMT2AALDH1A1MEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |