Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042817 | 0.91 | PKM (0.44) | GBA1KMT2ALMNAUSP2P2RX7 | |
| SCHEMBL20042685 | 0.88 | HTT (0.42) | GBA1SMN1; SMN2P2RX7TACR3KCNH2 | |
| SCHEMBL20042689 | 0.88 | P2RX7 (0.39) | HSD17B10GBA1SMN1; SMN2USP2CASP1 | |
| SCHEMBL20042687 | 0.88 | HSD17B10 (0.51) | HSD17B10GBA1KMT2ALMNAPOLB | |
| SCHEMBL20042839 | 0.88 | P2RX7 (0.45) | GBA1KMT2ASMN1; SMN2P2RX7MEN1 | |
| SCHEMBL20042886 | 0.88 | HPGD (0.49) | KMT2AP2RX7TACR3HPGD | |
| SCHEMBL20042752 | 0.88 | HPGD (0.47) | GBA1KMT2ALMNASMN1; SMN2P2RX7 | |
| SCHEMBL20042667 | 0.87 | TACR3 (0.46) | P2RX7TACR3KCNH2 | |
| SCHEMBL20042811 | 0.87 | HSD17B10 (0.60) | HSD17B10GBA1KMT2ALMNAPOLB | |
| SCHEMBL20042771 | 0.87 | P2RX7 (0.47) | KMT2ALMNASMN1; SMN2P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |