Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GPR6 | P46095 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | PRLHR | P49683 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042687 | 0.85 | HSD17B10 (0.51) | HSD17B10ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL20042811 | 0.84 | HSD17B10 (0.60) | HSD17B10ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL20042751 | 0.83 | HSD17B10 (0.49) | HSD17B10ALDH1A1HPGDKDM4EHTT | |
| SCHEMBL20042711 | 0.81 | HSD17B10 (0.50) | HSD17B10ALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL20042740 | 0.80 | HSD17B10 (0.49) | HSD17B10ALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL20042719 | 0.80 | HSD17B10 (0.46) | HSD17B10GPR6KMT2AGBA1MEN1 | |
| SCHEMBL20042827 | 0.80 | HSD17B10 (0.46) | HSD17B10ALDH1A1HPGDKMT2AGBA1 | |
| SCHEMBL20042715 | 0.79 | HSD17B10 (0.45) | HSD17B10ALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL20042728 | 0.78 | MEN1 (0.42) | ALDH1A1GPR6KMT2AGBA1MEN1 | |
| SCHEMBL20042980 | 0.78 | LSS (0.50) | HSD17B10ALDH1A1KDM4ENPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |