Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 3/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GBA1 | P04062 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042869 | 0.88 | PROKR1 (0.41) | PROKR1KDM4ESMN1; SMN2HSD17B10P2RX7 | |
| SCHEMBL20042868 | 0.86 | P2RX7 (0.35) | KDM4ESMN1; SMN2TP53POLBMEN1 | |
| SCHEMBL20042982 | 0.84 | P2RX7 (0.46) | SMN1; SMN2TP53POLBHSD17B10ALDH1A1 | |
| SCHEMBL20042958 | 0.84 | TACR3 (0.42) | TACR3KCNH2TACR2 | |
| SCHEMBL20042865 | 0.84 | TACR3 (0.42) | TACR3KCNH2TACR2 | |
| SCHEMBL20042851 | 0.84 | P2RX7 (0.46) | SMN1; SMN2TP53POLBHSD17B10ALDH1A1 | |
| SCHEMBL20042986 | 0.84 | TAS1R3 (0.40) | TP53P2RX7TACR3KCNH2THRB | |
| SCHEMBL20042876 | 0.84 | TAS1R3 (0.40) | TP53P2RX7TACR3KCNH2THRB | |
| SCHEMBL20043019 | 0.84 | POLB (0.34) | KDM4ETP53POLBHSD17B10MEN1 | |
| SCHEMBL20042857 | 0.84 | PROKR1 (0.35) | PROKR1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |