Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042876 | 0.90 | TAS1R3 (0.40) | P2RX7GRM5TP53THRBTDP1 | |
| SCHEMBL20042986 | 0.90 | TAS1R3 (0.40) | P2RX7GRM5TP53THRBTDP1 | |
| SCHEMBL20042853 | 0.88 | GPR6 (0.34) | P2RX7TP53THRBTDP1LMNA | |
| SCHEMBL20042841 | 0.87 | TACR2 (0.45) | GRM5TP53THRBTDP1LMNA | |
| SCHEMBL20042982 | 0.86 | P2RX7 (0.46) | P2RX7TP53POLBTHRBTDP1 | |
| SCHEMBL20042851 | 0.86 | P2RX7 (0.46) | P2RX7TP53POLBTHRBTDP1 | |
| SCHEMBL20042742 | 0.86 | PROKR1 (0.35) | P2RX7TP53POLBTHRBTDP1 | |
| SCHEMBL20043019 | 0.85 | POLB (0.34) | P2RX7GRM5TP53POLBTDP1 | |
| SCHEMBL20042852 | 0.83 | TACR3 (0.47) | P2RX7TACR1TACR2TACR3KCNH2 | |
| SCHEMBL20042883 | 0.83 | GPR6 (0.39) | P2RX7TP53THRBTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |