Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.51 |
| ▸ | PGR | P06401 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005613 | 0.90 | NR3C1 (0.62) | NR3C1PGRALDH1A1MEN1LMNA | |
| SCHEMBL2005610 | 0.90 | NR3C1 (0.62) | NR3C1PGRALDH1A1MEN1LMNA | |
| SCHEMBL2004688 | 0.88 | ALDH1A1 (0.47) | NR3C1PGRALDH1A1MEN1LMNA | |
| SCHEMBL2008102 | 0.77 | NR3C1 (0.40) | NR3C1PGRALDH1A1PTGS2PTGS1 | |
| SCHEMBL2008103 | 0.77 | NR3C1 (0.40) | NR3C1PGRALDH1A1PTGS2PTGS1 | |
| SCHEMBL2002007 | 0.74 | NR3C1 (0.82) | NR3C1PGRCNR2 | |
| SCHEMBL9254425 | 0.73 | ERN1 (0.49) | ALDH1A1MEN1KMT2ATSHRNPSR1 | |
| SCHEMBL1989561 | 0.73 | NR3C1 (0.53) | NR3C1PGRLMNAMAPTHTT | |
| SCHEMBL2008079 | 0.73 | NR3C1 (0.43) | NR3C1PGRALDH1A1MEN1LMNA | |
| SCHEMBL2002566 | 0.72 | NR3C1 (0.59) | NR3C1PGRMAPTCNR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960365-B2 | Compounds with medicinal effects due to interaction with the glucocorticoid receptor | N.V. ORGANON (NL) | 2011-06-14 | — | — | US | disclosed |