Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.82 |
| ▸ | PGR | P06401 | 4/20 | 0.82 |
| ▸ | CASR | P41180 | 4/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | RRM1 | P23921 | 2/20 | 0.37 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008107 | 0.90 | NR3C1 (1.00) | NR3C1PGRCASRSGK1 | |
| SCHEMBL2008086 | 0.86 | NR3C1 (0.78) | NR3C1PGRSGK1PIK3C3 | |
| SCHEMBL2008089 | 0.80 | NR3C1 (0.79) | NR3C1PGRSGK1PIK3C3 | |
| SCHEMBL2007374 | 0.79 | NR3C1 (0.79) | NR3C1PGRCASRSGK1PIK3C3 | |
| SCHEMBL2006541 | 0.78 | NR3C1 (0.62) | NR3C1PGRSGK1PIK3C3CHRM2 | |
| SCHEMBL2006930 | 0.78 | NR3C1 (0.78) | NR3C1PGRCASR | |
| SCHEMBL2007353 | 0.76 | NR3C1 (0.85) | NR3C1PGRSGK1PIK3C3 | |
| SCHEMBL2004275 | 0.74 | NR3C1 (0.51) | NR3C1PGRCNR2 | |
| SCHEMBL2009788 | 0.72 | NR3C1 (0.58) | NR3C1PGRSGK1CNR2PIK3C3 | |
| SCHEMBL2008128 | 0.69 | NR3C1 (0.54) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960365-B2 | Compounds with medicinal effects due to interaction with the glucocorticoid receptor | N.V. ORGANON (NL) | 2011-06-14 | — | — | US | disclosed |