SCHEMBL20042762

SCHEMBL20042762

Cc1nc2c(c(N3CCC3)n1)CN(C(=O)[C@H]1CC[C@H](C(F)(F)F)CC1)C2

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 2/20 0.40
GPR55 Q9Y2T6 2/20 0.40
GRM5 P41594 3/20 0.38
CNR2 P34972 1/20 0.36
LMNA P02545 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TSHR P16473 1/20 0.35
NR4A1 P22736 1/20 0.35
P2RX7 Q99572 2/20 0.34
GBA1 P04062 1/20 0.34
SPR P35270 4/20 0.33
MAPT P10636 2/20 0.32
POLB P06746 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
GPR6 P46095 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20042800 0.87 CNR1 (0.45) CNR1GPR55LMNASMN1; SMN2TSHR
SCHEMBL20042806 0.87 CNR1 (0.47) CNR1GPR55LMNASMN1; SMN2TSHR
SCHEMBL20042816 0.86 CNR1 (0.45) CNR1GPR55GRM5CNR2LMNA
SCHEMBL20042764 0.86 CNR1 (0.49) CNR1GPR55LMNASMN1; SMN2TSHR
SCHEMBL20042735 0.83 CNR2 (0.41) CNR1GPR55GRM5CNR2LMNA
SCHEMBL20042706 0.83 ALDH1A1 (0.43) CNR1GPR55CNR2LMNASMN1; SMN2
SCHEMBL20042779 0.82 GPR55 (0.39) CNR1GPR55CNR2LMNASMN1; SMN2
SCHEMBL20042793 0.82 SMN1; SMN2 (0.37) CNR1GPR55GRM5LMNASMN1; SMN2
SCHEMBL20042660 0.81 CNR1 (0.39) CNR1GPR55GRM5CNR2LMNA
Trifluoroacetic Acid SCHEMBL31614986 0.80 CCR4 (0.37) CNR1GPR55LMNASMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018066718-A1 THERAPEUTIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-04-12 WO disclosed