Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31614760 | 0.78 | SMN1; SMN2 (0.36) | LMNASMN1; SMN2KDM4ETSHRNR4A1 | |
| SCHEMBL20042971 | 0.78 | NAMPT (0.37) | — | |
| SCHEMBL20042901 | 0.77 | KCNH2 (0.38) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL20042797 | 0.77 | LMNA (0.42) | LMNAALDH1A1SMN1; SMN2KDM4EFAAH | |
| SCHEMBL20042990 | 0.75 | CNR1 (0.37) | LMNAALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL20042742 | 0.75 | PROKR1 (0.35) | ALDH1A1SMN1; SMN2KDM4EMAPK1HSD17B10 | |
| SCHEMBL31615020 | 0.73 | PDE10A (0.35) | LMNAALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL20042875 | 0.73 | PDE10A (0.35) | LMNAALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL20042885 | 0.73 | PIP5K1C (0.38) | LMNAALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL31614910 | 0.73 | PDE10A (0.35) | LMNAALDH1A1SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |