Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042791 | 0.80 | SMN1; SMN2 (0.37) | LMNAALDH1A1SMN1; SMN2TSHRNR4A1 | |
| SCHEMBL20042804 | 0.79 | ALDH1A1 (0.40) | LMNAALDH1A1SMN1; SMN2TSHRNR4A1 | |
| SCHEMBL20042786 | 0.77 | LMNA (0.36) | LMNAALDH1A1FAAHMGLLSMN1; SMN2 | |
| SCHEMBL20042870 | 0.76 | KDM4E (0.35) | LMNAALDH1A1SMN1; SMN2TSHRNR4A1 | |
| SCHEMBL20042776 | 0.76 | P2RX7 (0.41) | LMNASMN1; SMN2TSHRNR4A1P2RX7 | |
| SCHEMBL20042832 | 0.76 | CFTR (0.45) | LMNAALDH1A1SMN1; SMN2P2RX7KDM4E | |
| SCHEMBL20042839 | 0.75 | P2RX7 (0.45) | ALDH1A1SMN1; SMN2TSHRP2RX7MTOR | |
| SCHEMBL20042743 | 0.75 | P2RX7 (0.40) | SMN1; SMN2TSHRP2RX7MTORKDM4E | |
| SCHEMBL20042817 | 0.75 | PKM (0.44) | LMNAALDH1A1P2RX7KDM4EGBA1 | |
| SCHEMBL20042866 | 0.75 | NPY5R (0.33) | SMN1; SMN2MTORKDM4ECHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |