Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | PRLHR | P49683 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042752 | 0.93 | HPGD (0.47) | P2RX7HPGDCNR1CNR2GPR55 | |
| SCHEMBL20042886 | 0.93 | HPGD (0.49) | GPR6P2RX7HPGDTSHRTDP1 | |
| SCHEMBL20042789 | 0.92 | GPR6 (0.42) | GPR6HPGDGPR183PRLHRGBA1 | |
| SCHEMBL20042671 | 0.90 | P2RX7 (0.45) | P2RX7HPGDCNR1CNR2GPR55 | |
| SCHEMBL20042792 | 0.90 | TACR3 (0.46) | GPR6P2RX7HPGDCNR1CNR2 | |
| SCHEMBL20042782 | 0.90 | GPR6 (0.41) | GPR6P2RX7HPGDGPR183PRLHR | |
| SCHEMBL20042803 | 0.88 | GPR6 (0.40) | GPR6HPGDGPR183PRLHRGBA1 | |
| SCHEMBL20042944 | 0.88 | GPR183 (0.43) | GPR6HPGDGPR183PRLHRGBA1 | |
| SCHEMBL20042821 | 0.88 | MEN1 (0.41) | P2RX7HPGDALDH1A1TSHRHTT | |
| SCHEMBL20042667 | 0.88 | TACR3 (0.46) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |