SCHEMBL20043874

SCHEMBL20043874

CN1C[C@H](c2cc(F)cc(F)c2)[C@@H](C(=O)Nc2c(F)cccc2F)C1=O

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.38
CYP2C19 P33261 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
ALDH1A1 P00352 3/20 0.35
OPRK1 P41145 1/20 0.34
NPY5R Q15761 1/20 0.34
SMO Q99835 1/20 0.34
XIAP P98170 3/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
DHODH Q02127 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22621472 0.88 TP53 (0.40) ALDH1A1OPRK1NPY5RKMT2AMEN1
SCHEMBL22986865 0.88 TP53 (0.40) ALDH1A1OPRK1NPY5RKMT2AMEN1
SCHEMBL24310398 0.87 THRB (0.42) L3MBTL1ALDH1A1KMT2AMEN1MAPT
SCHEMBL20044247 0.87 THRB (0.42) L3MBTL1ALDH1A1KMT2AMEN1MAPT
SCHEMBL20043896 0.84 NPY5R (0.38) NPY5R
SCHEMBL21661950 0.84 P2RX7 (0.37) ALDH1A1NPY5RKMT2AMEN1MAPT
SCHEMBL20044099 0.83 TSHR (0.37) ALDH1A1NPY5RKMT2AMEN1MAPT
SCHEMBL20044096 0.83 TP53 (0.36) L3MBTL1KMT2A
SCHEMBL21662058 0.83 TP53 (0.45) L3MBTL1KMT2A
SCHEMBL20043915 0.82 THRB (0.41) L3MBTL1ALDH1A1KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 CYP3A4 475/4885CYP2C19 238/4885L3MBTL1 2969/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 CYP3A4 475/4885CYP2C19 238/4885L3MBTL1 2969/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 CYP3A4 475/4885CYP2C19 238/4885L3MBTL1 2969/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 CYP3A4 451/4885CYP2C19 230/4885L3MBTL1 3033/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 CYP3A4 475/4885CYP2C19 238/4885L3MBTL1 2969/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 CYP3A4 475/4885CYP2C19 238/4885L3MBTL1 2969/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 CYP3A4 475/4885CYP2C19 238/4885L3MBTL1 2969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.