SCHEMBL20043917

SCHEMBL20043917

Cc1cc(F)cc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccc(F)c(F)c2F)c1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
P2RX7 Q99572 1/20 0.36
EPHX2 P34913 10/20 0.36
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
NPC1 O15118 1/20 0.35
TAS1R3 Q7RTX0 1/20 0.34
TAS1R1 Q7RTX1 1/20 0.34
TAS1R2 Q8TE23 1/20 0.34
POLB P06746 1/20 0.34
KDM4E B2RXH2 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043948 0.91 TP53 (0.38) ALDH1A1P2RX7EPHX2LMNATSHR
SCHEMBL25893566 0.91 TP53 (0.38) ALDH1A1P2RX7EPHX2LMNATSHR
SCHEMBL25893559 0.89 LMNA (0.38) EPHX2LMNATSHRGAA
SCHEMBL20043871 0.88 ALDH1A1 (0.44) ALDH1A1P2RX7EPHX2TSHRNPC1
SCHEMBL20048591 0.88 ALDH1A1 (0.41) ALDH1A1EPHX2LMNATSHRNPC1
SCHEMBL20048550 0.87 ALDH1A1 (0.43) ALDH1A1P2RX7EPHX2LMNATSHR
SCHEMBL20044104 0.87 ALDH1A1 (0.39) ALDH1A1P2RX7EPHX2TSHRNPC1
SCHEMBL20043950 0.87 MEN1 (0.43) ALDH1A1EPHX2LMNATSHRNPC1
SCHEMBL20043885 0.86 LMNA (0.35) ALDH1A1P2RX7LMNATSHRKDM4E
SCHEMBL20044016 0.85 TP53 (0.40) ALDH1A1EPHX2LMNATSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885P2RX7 866/4885EPHX2 317/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885P2RX7 866/4885EPHX2 317/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885P2RX7 866/4885EPHX2 317/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1182/4885P2RX7 869/4885EPHX2 330/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885P2RX7 866/4885EPHX2 317/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885P2RX7 866/4885EPHX2 317/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885P2RX7 866/4885EPHX2 317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.