SCHEMBL20043885

SCHEMBL20043885

Cc1ccc(NC(=O)[C@H]2C(=O)N(C)C[C@@H]2c2cc(F)cc(F)c2)c(F)c1F

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.35
KDM4E B2RXH2 3/20 0.35
P2RX7 Q99572 3/20 0.34
ALDH1A1 P00352 2/20 0.34
ABL1 P00519 1/20 0.33
HSD17B10 Q99714 2/20 0.32
GAA P10253 1/20 0.32
MAPK1 P28482 1/20 0.32
HTR7 P34969 1/20 0.31
ALPI P09923 1/20 0.31
NPY5R Q15761 1/20 0.31
GLA P06280 1/20 0.31
TSHR P16473 2/20 0.31
CHRM3 P20309 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043917 0.86 ALDH1A1 (0.41) LMNAKDM4EP2RX7ALDH1A1GAA
SCHEMBL22621472 0.85 TP53 (0.40) LMNAKDM4EP2RX7ALDH1A1NPY5R
SCHEMBL22986865 0.85 TP53 (0.40) LMNAKDM4EP2RX7ALDH1A1NPY5R
SCHEMBL20043873 0.85 LMNA (0.39) LMNAGAAGLATSHR
SCHEMBL21662058 0.84 TP53 (0.45)
SCHEMBL20044096 0.83 TP53 (0.36) CHRM3
SCHEMBL20043871 0.82 ALDH1A1 (0.44) P2RX7ALDH1A1TSHR
SCHEMBL20044104 0.82 ALDH1A1 (0.39) P2RX7ALDH1A1TSHR
SCHEMBL24310398 0.82 THRB (0.42) LMNAALDH1A1ABL1GAA
SCHEMBL20044247 0.82 THRB (0.42) LMNAALDH1A1ABL1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 LMNA 3917/4885KDM4E 2181/4885P2RX7 866/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 LMNA 3917/4885KDM4E 2181/4885P2RX7 866/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 LMNA 3917/4885KDM4E 2181/4885P2RX7 866/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 LMNA 3944/4885KDM4E 2149/4885P2RX7 869/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 LMNA 3917/4885KDM4E 2181/4885P2RX7 866/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 LMNA 3917/4885KDM4E 2181/4885P2RX7 866/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 LMNA 3917/4885KDM4E 2181/4885P2RX7 866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.