SCHEMBL20044082

SCHEMBL20044082

CN1C[C@H](c2cc(F)cc(Cl)c2)[C@@H](C(=O)Nc2ccccc2F)C1=O

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
MAPT P10636 1/20 0.43
ALDH1A1 P00352 3/20 0.40
LMNA P02545 1/20 0.40
KDM4E B2RXH2 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
TSHR P16473 1/20 0.38
CHRM3 P20309 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
EPHX2 P34913 1/20 0.37
MDM2 Q00987 2/20 0.36
TP53 P04637 1/20 0.36
BRD4 O60885 1/20 0.36
NPC1 O15118 1/20 0.36
PKM P14618 1/20 0.36
P2RX7 Q99572 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044345 0.95 KMT2A (0.45) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20044080 0.92 TP53 (0.37) MEN1KMT2AMAPTALDH1A1CHRM3
SCHEMBL20044085 0.91 THRB (0.39) MEN1KMT2AMAPTSMN1; SMN2CHRM3
SCHEMBL20044081 0.90 MAPT (0.41) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20043950 0.89 MEN1 (0.43) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20044458 0.88 MEN1 (0.40) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20044810 0.88 MEN1 (0.40) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20044086 0.88 F10 (0.39) CHRM3MDM2TP53
SCHEMBL20044343 0.87 TP53 (0.39) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20048548 0.86 MEN1 (0.45) MEN1KMT2AMAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885MAPT 3629/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885MAPT 3629/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885MAPT 3629/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3362/4885KMT2A 1693/4885MAPT 3633/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885MAPT 3629/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885MAPT 3629/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885MAPT 3629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.