SCHEMBL20044086

SCHEMBL20044086

CN1C[C@H](c2cc(F)cc(Cl)c2)[C@@H](C(=O)Nc2ccccc2S(C)(=O)=O)C1=O

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
F10 P00742 5/20 0.39
MDM2 Q00987 5/20 0.36
TP53 P04637 4/20 0.36
CHRM3 P20309 2/20 0.35
FPR1 P21462 3/20 0.35
FPR2 P25090 3/20 0.35
METAP2 P50579 2/20 0.35
CNR2 P34972 1/20 0.35
JAK2 O60674 1/20 0.34
JAK1 P23458 1/20 0.34
TYK2 P29597 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043861 0.93 CNR2 (0.38) F10CHRM3CNR2JAK2JAK1
SCHEMBL20044826 0.88 F10 (0.36) F10FPR1FPR2CNR2JAK2
SCHEMBL20048447 0.88 CNR2 (0.37) F10CNR2JAK2JAK1TYK2
SCHEMBL20044082 0.88 MEN1 (0.43) MDM2TP53CHRM3
SCHEMBL20043982 0.87 CA1 (0.39) F10FPR1FPR2CNR2JAK2
SCHEMBL20044081 0.86 MAPT (0.41) MDM2TP53CHRM3
SCHEMBL20044763 0.84 CNR2 (0.40) F10CNR2JAK2JAK1TYK2
SCHEMBL20044080 0.84 TP53 (0.37) MDM2TP53CHRM3
SCHEMBL20044003 0.83 FPR2 (0.36) F10FPR1FPR2CNR2JAK2
SCHEMBL20044822 0.83 FPR2 (0.36) FPR1FPR2CNR2JAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 F10 3703/4885MDM2 301/4885TP53 1193/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 F10 3703/4885MDM2 301/4885TP53 1193/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 F10 3703/4885MDM2 301/4885TP53 1193/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 F10 3694/4885MDM2 311/4885TP53 1230/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 F10 3703/4885MDM2 301/4885TP53 1193/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 F10 3703/4885MDM2 301/4885TP53 1193/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 F10 3703/4885MDM2 301/4885TP53 1193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.