Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229631 | 0.85 | NOS2 (0.65) | POLBCYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL20045031 | 0.82 | NOS2 (0.49) | POLBCLK4ALDH1A1MEN1KMT2A | |
| SCHEMBL16220824 | 0.81 | NOS2 (0.72) | POLBL3MBTL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL18466143 | 0.78 | L3MBTL1 (0.53) | POLBL3MBTL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8229603 | 0.77 | KDM4E (0.54) | POLBALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3948160 | 0.76 | ALDH1A1 (0.77) | POLBL3MBTL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL25068904 | 0.76 | FFAR1 (0.52) | CYP1A2CYP3A4CYP2C19CLK4CYP2D6 | |
| SCHEMBL19171724 | 0.75 | NPC1 (0.46) | POLBL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8224486 | 0.75 | CLK4 (0.54) | POLBCLK4ALDH1A1MEN1KMT2A | |
| SCHEMBL20656683 | 0.74 | CYP1A2 (0.56) | L3MBTL1CYP1A2CYP2D6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180098987-A1 | PRMT5 Inhibitors and Uses Thereof | Epizyme, Inc. (US) | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180098987-A1 | PRMT5 Inhibitors and Uses Thereof | PRMT5, PRMT1, PRMT6 | POLB 2005/4885L3MBTL1 982/4885CYP1A2 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.