Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27596223 | 0.98 | TDP1 (0.50) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL9450434 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL3751620 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL2238176 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL24188 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL2358014 | 0.80 | ATM (0.64) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL10964872 | 0.79 | CES2 (0.52) | L3MBTL1CES2CES1ATMGAA | |
| Water SCHEMBL27597000 | 0.78 | TDP1 (0.54) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL11287856 | 0.78 | TDP1 (0.54) | TDP1L3MBTL1CES2CES1ATM | |
| SCHEMBL27548850 | 0.78 | TDP1 (0.54) | TDP1L3MBTL1CES2CES1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106966914-B | A kind of preparation method of the chloro- 2- aminoacetophenone of the bromo- 4- of 5- | 无锡捷化医药科技有限公司 | 2019-02-22 | — | — | CN | claimed |
| CN-106966914-A | A kind of preparation method of the aminoacetophenone of 5 bromine, 4 chlorine 2 | 无锡捷化医药科技有限公司 | 2017-07-21 | — | — | CN | claimed |
| CN-106966914-B | A kind of preparation method of the chloro- 2- aminoacetophenone of the bromo- 4- of 5- | 无锡捷化医药科技有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-106966914-B | A kind of preparation method of the chloro- 2- aminoacetophenone of the bromo- 4- of 5- | 无锡捷化医药科技有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-106966914-B | A kind of preparation method of the chloro- 2- aminoacetophenone of the bromo- 4- of 5- | 无锡捷化医药科技有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-106966914-A | A kind of preparation method of the aminoacetophenone of 5 bromine, 4 chlorine 2 | 无锡捷化医药科技有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-102924359-B | Method for synthesizing substituted indole compounds through one-pot method | YANTAI INST COASTAL ZONE RES CAS | 2015-03-11 | — | — | CN | disclosed |
| US-8721942-B2 | Composite membrane including coating of polyalkylene oxide and acetophenone compounds | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-05-13 | — | — | US | disclosed |
| CN-102924359-A | Method for synthesizing substituted indole compounds through one-pot method | YANTAI INST COASTAL ZONE RES CAS | 2013-02-13 | — | — | CN | disclosed |
| WO-2011112351-A1 | POLYAMIDE MEMBRANE WITH A COATING COMPRISING POLYALKYLENE OXIDE AND ACETOPHENONE COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-09-15 | — | — | WO | disclosed |
| US-20110220569-A1 | COMPOSITE MEMBRANE INCLUDING COATING OF POLYALKYLENE OXIDE AND ACETOPHENONE COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC | 2011-09-15 | — | — | US | disclosed |
| WO-2009140467-A1 | OXOBENZINDOLIZINOQUINOLINES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2009-11-19 | — | — | WO | disclosed |
| US-7592361-B2 | (5-{3-[4-(4,5,6,7-tetrahydro-benzooxazol-2-yl)-phenoxy]-propoxy}-indol-1-yl)-acetic acid; diabetes, obesity, hyperlipidemia, and atherosclerotic disease | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| EP-1620088-A4 | INDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | BAYER PHARMACEUTICALS CORP (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20060264486-A1 | Indole acetic acid derivatives and their use as pharmaceutical agents | BAYER HEALTHCARE LLC | 2006-11-23 | — | — | US | disclosed |
| EP-1620088-A2 | INDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | Bayer Pharmaceuticals Corporation (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098498-A2 | INDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-18 | — | — | WO | disclosed |
| CN-1046731-C | Pyrrolo [2,3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1999-11-24 | — | — | CN | disclosed |
| US-5969184-A | INTERMEDIATES FOR COMPOUNDS WHICH CONTROL PRODUCTION OF EXCESSIVE INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| CN-1164234-A | Pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1997-11-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264486-A1 | Indole acetic acid derivatives and their use as pharmaceutical agents | IDO1, IDO2, AADAT | TDP1 2712/4885L3MBTL1 3646/4885CES2 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.