Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 8/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SHBG | P04278 | 2/20 | 0.33 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | G6PD | P11413 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20048102 | 1.00 | PDK1 (0.34) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL23653757 | 0.90 | — | — | |
| SCHEMBL21729782 | 0.87 | PDK1 (0.34) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL21143403 | 0.87 | PDK1 (0.39) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL21143415 | 0.87 | ESR1 (0.37) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL20048225 | 0.87 | ESR1 (0.37) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL20048226 | 0.87 | ESR1 (0.37) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL9019868 | 0.86 | PDK1 (0.36) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL21470230 | 0.85 | PGR (0.44) | PDK1PDK2PDK3PDK4ESR1 | |
| SCHEMBL8539498 | 0.85 | PDK1 (0.37) | PDK1PDK2PDK3PDK4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230096870-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2023-03-30 | — | — | US | disclosed |
| EP-3851444-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | Oric Pharmaceuticals, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| CN-111690031-B | Glucocorticoid receptor inhibitors | 欧瑞克制药公司 | 2021-06-01 | — | — | CN | disclosed |
| EP-3523315-B1 | INHIBITOR OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS INC (US) | 2021-03-24 | — | — | EP | disclosed |
| EP-3523315-B1 | INHIBITOR OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS INC (US) | 2021-03-24 | — | — | EP | disclosed |
| US-20210017219-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2021-01-21 | — | — | US | disclosed |
| US-20210017219-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2021-01-21 | — | — | US | disclosed |
| US-10836789-B2 | Inhibitors of glucocorticoid receptor | ORIC PHARMACEUTICALS, INC. (US) | 2020-11-17 | — | — | US | disclosed |
| US-10836789-B2 | Inhibitors of glucocorticoid receptor | ORIC PHARMACEUTICALS, INC. (US) | 2020-11-17 | — | — | US | disclosed |
| CN-111690031-A | Glucocorticoid receptor inhibitors | 欧瑞克制药公司 | 2020-09-22 | — | — | CN | disclosed |
| US-20200291058-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2020-09-17 | — | — | US | disclosed |
| US-10723759-B2 | Inhibitors of glucocorticoid receptor | ORIC PHARMACEUTICALS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-10723759-B2 | Inhibitors of glucocorticoid receptor | ORIC PHARMACEUTICALS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20200055892-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2020-02-20 | — | — | US | disclosed |
| US-20200055892-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2020-02-20 | — | — | US | disclosed |
| US-10472387-B2 | Inhibitors of glucocorticoid receptor | ORIC PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-10472387-B2 | Inhibitors of glucocorticoid receptor | ORIC PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20190218246-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2019-07-18 | — | — | US | disclosed |
| US-20190218246-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2019-07-18 | — | — | US | disclosed |
| WO-2018068021-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472387-B2 | Inhibitors of glucocorticoid receptor | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-20190218246-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-20210017219-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-20200055892-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-10836789-B2 | Inhibitors of glucocorticoid receptor | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-10723759-B2 | Inhibitors of glucocorticoid receptor | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-20200291058-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
| US-20230096870-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | NR3C1, NR3C2, MC2R | PDK1 1017/4885PDK2 1303/4885PDK3 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.