SCHEMBL20048451

SCHEMBL20048451

CN1C[C@H](c2ccc(C(F)(F)F)cc2)[C@@H](C(=O)Nc2ccc(F)c(F)c2F)C1=O

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
MEN1 O00255 1/20 0.38
TSHR P16473 1/20 0.38
KMT2A Q03164 1/20 0.38
ROCK1 Q13464 1/20 0.38
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
TAS1R2 Q8TE23 1/20 0.37
EPHX2 P34913 7/20 0.36
TACR1 P25103 1/20 0.36
KCNH2 Q12809 1/20 0.36
NPC1 O15118 1/20 0.35
TRPM8 Q7Z2W7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044544 0.92 ROCK1 (0.37) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL20044671 0.92 ROCK1 (0.41) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL20044669 0.92 P2RX7 (0.39) MEN1TSHRKMT2AROCK1TACR1
SCHEMBL20044666 0.92 MEN1 (0.38) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL20044670 0.91 P2RX7 (0.39) MEN1TSHRKMT2AROCK1TACR1
SCHEMBL18281133 0.91 TRPM8 (0.41) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL20044494 0.91 ROCK1 (0.38) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL30581574 0.91 TRPM8 (0.41) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL18815248 0.91 TRPM8 (0.41) ALDH1A1MEN1TSHRKMT2AROCK1
SCHEMBL20044312 0.90 ALDH1A1 (0.42) ALDH1A1MEN1TSHRKMT2AROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885TSHR 1106/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885TSHR 1106/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885TSHR 1106/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1182/4885MEN1 3362/4885TSHR 1114/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885TSHR 1106/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885TSHR 1106/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885TSHR 1106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.