Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23408299 | 0.79 | RIPK1 (0.33) | TRPV1 | |
| SCHEMBL24345433 | 0.76 | KMT2A (0.40) | TRPV1 | |
| SCHEMBL15715213 | 0.76 | HSD17B10 (0.32) | IRAK4 | |
| SCHEMBL22142676 | 0.75 | RAB9A (0.42) | — | |
| SCHEMBL15688867 | 0.72 | IRAK4 (0.30) | IRAK4 | |
| SCHEMBL18876080 | 0.71 | ALOX5AP (0.33) | ALOX5AP | |
| SCHEMBL17132580 | 0.71 | IRAK4 (0.33) | IRAK4 | |
| SCHEMBL19435503 | 0.71 | TAAR1 (0.38) | — | |
| SCHEMBL25079008 | 0.71 | P4HB (0.32) | — | |
| SCHEMBL14093000 | 0.70 | ALDH1A1 (0.37) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |