Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049678 | 0.89 | NR1H2 (0.45) | CACNA1HCACNA1BCACNA1CGLSLMNA | |
| SCHEMBL15862359 | 0.86 | GAA (0.43) | GLSALDH1A1GAAGFERKDM4A | |
| SCHEMBL2986153 | 0.84 | ALDH1A1 (0.51) | GLSALDH1A1GAAGFERKDM4A | |
| SCHEMBL14420097 | 0.81 | ALDH1A1 (0.48) | PDK2LMNAALDH1A1GAAGFER | |
| SCHEMBL20049569 | 0.81 | NOTUM (0.52) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL24971039 | 0.80 | CACNA1H (0.46) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL16739703 | 0.80 | IDO1 (0.46) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL5209897 | 0.79 | L3MBTL1 (0.52) | LMNAALDH1A1GAAKDM4AL3MBTL1 | |
| SCHEMBL20049606 | 0.79 | EPHX2 (0.46) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL8786913 | 0.77 | GLS (0.57) | GLSKDM4ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11207283-B2 | Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | NORTHWESTERN UNIVERSITY (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200281880-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | NORTHWESTERN UNIVERSITY (US) | 2020-09-10 | — | — | US | disclosed |
| US-10632088-B2 | Inactivators of Toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | NORTHWESTERN UNIVERSITY (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180098952-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | NORTHWESTERN UNIVERSITY (US) | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180098952-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | OAT, OTC, ABAT | CACNA1H 3422/4885CACNA1B 4553/4885CACNA1C 4612/4885 |
| US-11207283-B2 | Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | OAT, OTC, ABAT | CACNA1H 3422/4885CACNA1B 4553/4885CACNA1C 4612/4885 |
| US-20200281880-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | OAT, OTC, ABAT | CACNA1H 3422/4885CACNA1B 4553/4885CACNA1C 4612/4885 |
| US-10632088-B2 | Inactivators of Toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | OAT, OTC, ABAT | CACNA1H 3422/4885CACNA1B 4553/4885CACNA1C 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.