Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049934 | 0.90 | KMT2A (0.56) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL9006023 | 0.88 | KMT2A (0.70) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL9006022 | 0.88 | KMT2A (0.70) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL11592418 | 0.83 | KMT2A (0.53) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL6319902 | 0.83 | KMT2A (0.66) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| Hydrochloric Acid SCHEMBL11593188 | 0.82 | KMT2A (0.55) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL20049942 | 0.82 | ADRB2 (0.51) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL10743819 | 0.81 | CYP2D6 (0.81) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL8266174 | 0.81 | ADRB2 (1.00) | CYP2D6ADRB1ADRB3ADRB2KMT2A | |
| SCHEMBL27277524 | 0.81 | ADRB1 (0.71) | CYP2D6ADRB1ADRB3ADRB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673853-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673853-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-06-13 | — | — | US | disclosed |
| US-20220153685-A1 | SMALL MOLECULE AMPK ACTIVATORS | THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS TECHNOLOGY TRANSFER PROGRAM (10P9TT) | 2022-05-19 | — | — | US | disclosed |
| US-11040935-B2 | Small molecule AMPK activators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-06-22 | — | — | US | disclosed |
| US-20200062693-A1 | SMALL MOLECULE AMPK ACTIVATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2020-02-27 | — | — | US | disclosed |
| WO-2018067685-A1 | SMALL MOLECULE AMPK ACTIVATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673853-B2 | Small molecule AMPK activators | PRKAG1, PRKAG2, PRKAA1 | CYP2D6 4621/4885ADRB1 2843/4885ADRB3 2977/4885 |
| US-20220153685-A1 | SMALL MOLECULE AMPK ACTIVATORS | PRKAG1, PRKAG2, PRKAA1 | CYP2D6 4621/4885ADRB1 2843/4885ADRB3 2977/4885 |
| US-11040935-B2 | Small molecule AMPK activators | PRKAG1, PRKAG2, PRKAA1 | CYP2D6 4621/4885ADRB1 2843/4885ADRB3 2977/4885 |
| US-20200062693-A1 | SMALL MOLECULE AMPK ACTIVATORS | PRKAG1, PRKAG2, PRKAA1 | CYP2D6 4621/4885ADRB1 2843/4885ADRB3 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.