Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 13/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25586426 | 0.92 | GRIN2B (0.45) | CHRNA7GRIN2BGRIN1DYRK1A | |
| SCHEMBL25588372 | 0.90 | CHRNA7 (0.40) | CHRNA7PDGFRBPDGFRAGRIN2BAPP | |
| SCHEMBL25583779 | 0.83 | CHRNA7 (0.49) | CHRNA7PDGFRBPDGFRAGRIN2B | |
| SCHEMBL20050011 | 0.83 | USP2 (0.40) | CHRNA7PDGFRBPDGFRA | |
| SCHEMBL20050005 | 0.82 | GRIN2B (0.38) | CHRNA7GRIN2BGRIN1 | |
| SCHEMBL20049991 | 0.81 | PDGFRB (0.40) | CHRNA7PDGFRBPDGFRAGRIN2BGRIN1 | |
| SCHEMBL20050084 | 0.81 | MAP4K4 (0.48) | PDGFRBPDGFRAGRIN2BGRIN1CYP17A1 | |
| SCHEMBL20049954 | 0.80 | PDGFRB (0.41) | CHRNA7PDGFRBPDGFRA | |
| SCHEMBL20050002 | 0.77 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL23283131 | 0.76 | KIF11 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |