Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006787 | 0.94 | PTGES2 (0.36) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2005302 | 0.92 | L3MBTL1 (0.35) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2007874 | 0.91 | FAAH (0.41) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2002764 | 0.90 | PTGES2 (0.36) | PTGES2MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL2007516 | 0.89 | S1PR3 (0.38) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2002225 | 0.89 | ALOX5AP (0.39) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2006664 | 0.89 | ALOX5AP (0.36) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2009612 | 0.89 | MEN1 (0.42) | ALOX5APALOX5MAPTPKMALDH1A1 | |
| SCHEMBL2004892 | 0.89 | LMNA (0.35) | ALOX5APALOX5PTGES2MAPTKDM4E | |
| SCHEMBL2005424 | 0.88 | ALOX5AP (0.42) | ALOX5APALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |