Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.57 |
| ▸ | CTSG | P08311 | 2/20 | 0.47 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30875731 | 0.87 | ELANE (0.53) | ELANECTSGPRTN3ALDH1A1MEN1 | |
| SCHEMBL18517357 | 0.75 | MEN1 (0.54) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL19971697 | 0.75 | MEN1 (0.54) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL19971698 | 0.75 | MEN1 (0.54) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL11772829 | 0.71 | ELANE (0.68) | ELANECTSGPRTN3ALDH1A1MEN1 | |
| SCHEMBL9031247 | 0.71 | ALDH1A1 (0.53) | ELANECTSGALDH1A1MEN1KMT2A | |
| SCHEMBL6049147 | 0.71 | ALDH1A1 (0.53) | ELANECTSGALDH1A1MEN1KMT2A | |
| SCHEMBL2870534 | 0.71 | CACNA1G (0.48) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL13168448 | 0.70 | FKBP1A (0.45) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL1190867 | 0.70 | ALDH1A1 (0.44) | ELANEALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944613-B2 | Fumagillol spirocyclic compounds and fused bicyclic compounds and methods of making and using same | ZAFGEN, INC. (US) | 2018-04-17 | — | — | US | disclosed |